UEMS Medical Specialty
Metabolic & Endocrinology — Page 2
Nutraceutical approaches to metabolic dysregulation: GLP-1 companion formulas, insulin sensitisers, thyroid support, adipokine modulation, and comprehensive metabolic syndrome management.
26
dossiers
Precision Microbiome & Gut-Brain Axis
Enteric Delivery of Butyrate: Overcoming Gastrointestinal Barriers for Vagal Activation
Free butyrate salts dissolve prematurely in the upper gastrointestinal tract, limiting their availability for distal gut signaling. Additionally, their pungent odor and taste present significant challenges for patient adherence in chronic applications.
Post-GLP-1 Metabolic Optimization
Semaglutide: Gastrointestinal Effects and Post-Discontinuation Weight Regain, 2026
Developing GLP-1 formulations that balance robust metabolic benefits with reduced gastrointestinal side effects and mitigate post-discontinuation weight regain remains a significant challenge. The interplay between appetite modulation, gastrointestinal motility, and adverse event profiles adds complexity to product optimization.
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