HOW THE DECISION IS BUILT
Eight decision phases. One controlled evidence trail.
The scientific spine is consistent, but the module manifest changes with the product category, population, named countries, delivery system, portfolio structure, and risk profile. Paid Discovery determines what the concept survives before practical validation, external testing, pilot work, or production commitments begin.
AI-ASSISTED RESEARCH · SOURCE-AUDITED DECISIONS
AI-assisted search expands the reachable literature and regulatory surface; it does not become the scientific authority. Material conclusions are tied to primary or authoritative sources, exact form and exposure, null and contradictory findings, an independent review step, and an explicit evidence boundary.
Why We Cannot Provide Production Quotes Without This Process.
A spreadsheet can accept an incoherent product. A permitted component or accepted filing does not establish scientific integrity, finished-product efficacy, absence of interactions, or industrial feasibility. We therefore separate due diligence from production pricing and require the relevant decision gates before practical execution.
RESEARCH SERVICES · METHODOLOGICAL SUPPORT
Where a programme needs a stronger evidence package, Paid Discovery can define the methodological support for literature reviews used in evidence-based scientific assessments: research-question framing, inclusion and exclusion logic, evidence hierarchy, endpoint relevance, contradiction logging and dossier-ready synthesis for the locked brief.
PHASE 1
Biological Systems Map
We convert the intended function into biological equations: compartments, cells, receptors, enzymes, transporters, feedback loops, timing, measurable endpoints, and over-targeting risk. No ingredient enters the candidate pool until the causal system is defined.
Mechanism map · over-targeting risks · measurable endpoints
PHASE 2
Cross-Condition Discovery & Evidence Architecture
We temporarily leave the consumer category and search other fields for the same causal architecture. Candidate routes are then tested for human exposure, target access, dose, source, form, and functional relevance, while null and contradictory evidence remains visible.
Cross-condition map · Master Evidence Pool · translational verdicts
PHASE 3
Applicability-Driven Screening
Candidates pass through the scientific, source, category, jurisdiction, allergen, certification, dosage-form, stability, safety, and commercial gates activated by the signed brief. Every elimination and unresolved condition remains auditable.
Screening audit · conditional routes · rejected and unresolved register
PHASE 4
Category, Jurisdiction & Claims Architecture
We determine the product route and what may lawfully be communicated in every named country. Science, legal status, and claimability remain separate, so an authorised claim never substitutes for biological fit.
Country-by-country pathway · claims and prohibited-language matrix · warning inputs
PHASE 5
Product/System Architecture & Dose Integrity
We assign each component a defined role, verify its source, form, and evidence-supported exposure, and test the quantitative architecture against the intended delivery system, use pattern, and multi-product system. Decorative inclusion is rejected.
Controlled product architecture · dose and role justification · removal priority
PHASE 6
Safety, Synergy & Clinical Interaction Review
We examine individual and organ-system toxicology, intended synergy, antagonism, within-product interactions, and cumulative exposure across every product intended for combined use. The review extends to relevant medicines, CYP450, conjugation enzymes, transporters, vulnerable populations, timing, monitoring, and stop conditions.
Safety dossier · synergy/antagonism · multi-product exposure · drug/CYP/transporter review
PHASE 7
Theoretical Technical & Galenic Feasibility
The selected architecture is tested against the physics and chemistry of the actual delivery system: mass or phase balance, solubility, flow or rheology, compatibility, degradation, packaging, analytical readiness, and missing material data.
Theoretical feasibility verdict · risk matrix · physical validation plan
PHASE 8
Controlled Dossier & Decision Route
Every contracted conclusion is tied to a controlled artifact, source set, reviewer, version, limitation, and decision. The release states whether to proceed, redesign, pause, or stop, and identifies the separately paid physical or regulatory work required next.
Controlled deliverables register · decision record · next work-order map
The same name does not establish the same product: source, form, standardisation, process, matrix, route, exposure, population, and use pattern can all change the scientific, safety, legal, and technical conclusion. Paid Discovery records those boundaries before they become expensive physical errors.